In controls, posterior cingulate cortex was activated during response switching and deactivated during response repetition, whereas alcoholics showed the opposite pattern, and greater deviations from the normal activity correlated with higher amounts of lifetime alcohol consumption. A functional dissociation of brain network connectivity between the groups further showed that the controls exhibited greater corticocortical connectivity among medial prefrontal, middle cingulate, and posterior cingulate cortices than the alcoholics. In contrast, the alcoholics exhibited greater orbitofrontal-midbrain network connectivity than the controls.
