the same methods applied to BMI do not capture much more than half of the expected genotypic variance, and it is not clear that they are as efficient for schizophrenia, arthritis or intelligence75,76. In these cases, it can be argued that the infinitesimal model does not capture the full range of genetic variance, and that there is a true missing heritability problem that will need to be addressed with rare alleles and broad sense heritability components that were introduced in Box 1.
