The frequency of genotypes in 15q25 SNPs, rs8034191, rs931794, and rs1051730, in the white population was consistent with reported frequencies in the GWAS studies.6–8 This is the first report on the frequency of these genotypes in African Americans. Among African Americans, the homozygous rare variant genotypes for each SNP were relatively uncommon and occurred in fewer than 6% of the controls. A recent study in Asians evaluated seven SNPs in this region including rs8034191 and rs1051730.16 Allele frequencies in Asians for these two SNPs were lower than what we observed in whites and African Americans in our study; for rs8034191 the minor allele frequencies were reported to be 0.37, 0.16, and 0.02 in whites, African Americans, and Asians, respectively. Likewise, for rs1051730 the minor allele frequencies were reported to be 0.37, 0.10, and 0.01 in whites, African Americans and Asians, respectively.
