iPSC lines to address inter- and intra-cell line variability and the limited ability of cultures to replicate the prolonged and complex development of the human nervous system in vivo. Finally, our finding that nearly half of iPSC lines produce neural cultures with strikingly low levels of expression of the chr4p12 GABAA gene cluster may be of interest to other investigators using this model system to examine neuropsychiatric conditions, particularly if only a limited number of disease and control donor lines are compared.
