Chunk #12 — Materials and Methods — Subjects, genotyping and assignment of nominal significance of dependent vs control allele frequencies in each sample — 4) Monte Carlo methods for assignment of levels of significance to: a) the extent of clustering in each sample and b) the degree to which clustered nominally-positive SNPs from multiple independent samples identify the same chromosomal regions
Monte Carlo methods were used to assign empirical statistical probabilities to two null hypotheses, starting with the sets of all SNPs and the nominally positive SNPs that displayed p<0.05 case vs control values.
