The unique application of the aMEG analysis in TF domain in the context of alcohol intoxication has revealed several findings pertaining to lexical-semantic processing. Event-related theta power estimated to the left-lateralized temporo-prefrontal cortex was sensitive to lexical-semantic retrieval during lexical decision task. Theta power estimated primarily to the lateral and medial prefrontal areas additionally reflected decision conflict on the imperative AN trials. Whereas alcohol reduced theta power overall across all processing stages, its effects were selective for the lexical-semantic retrieval conditions as the theta to PW was not affected. This indicates that the synchronized activity in theta range underlies lexical-semantic retrieval in the left fronto-temporal areas which is vulnerable to alcohol intoxication. These effects are discussed seriatim in greater detail.
