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Chunk #21 — 3. Capturing Common Variation — 3.3 Indirect Association

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Chapter 11: Genome-wide association studies.
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Conceptually, the end result of GWAS under the common disease/common variant hypothesis is that a panel of 500,000 to one million markers will identify common SNPs that are associated to common phenotypes. To conduct such a study practically requires a genotyping technology that can accurately capture the alleles of 500,000 to one million SNPs for each individual in a study in a cost-effective manner.