These PRS studies were all performed in European-ancestry populations, and expansion to worldwide populations is essential. For example, a study of lung cancer-associated variants in Chinese populations [51] demonstrated that PRS was an independent risk stratification indicator for lung cancer beyond age and smoking pack-years. Polygenic risk scores have been less widely applied to auto-immune disorders. In type 1 diabetes, strong genetic risk scores have been created, with the large effect of the HLA haplotypes increasing AUC values to > 0.8 in European ancestry and Hispanic populations [52]. An ancestry-specific genetic score using 7 SNPs outperformed a European-based genetic score in African ancestry participants (AUC 0.87 and 0.80, respectively) [53].
