(DL vs. DM & DL vs. SH) per analysis. Moreover, in addition to the question of the number of independent analyses on which to base a correction, it is not even clear whether corrections should be made with respect to specific comparisons between trajectory classes, or at the omnibus level of overall SNP effects across trajectory classes. So, although nine separate models were run to address each of the genetically informative hypotheses (i.e., main and interactive effects), we chose both to present significance values corresponding to the uncorrected alpha (.05), and to highlight those effects which held up to the highly conservative Bonferroni correction of α = .0056. We note, however, that the best threshold is likely somewhere in between (Ziegler et al., 2008).
