this difference was individually detected for each of five traits (all one-tailed difference of means P < 3.4 × 10−6). This trend was not as strong when comparing IMPACT to CTS (R2 = 2.6%, s.e.m. = 0.5%, one-tailed paired Wilcoxon P = 0.06), although this difference was detected individually for three of five traits (three one-tailed difference of means P < 1.1 × 10−4). We performed a similar bootstrap analysis as above, yielding similar results; only for RA and asthma did IMPACT-PRS not produce consistently greater R2 estimates than CTS-PRS (Supplementary Table 20).
