Chunk #31 — Methods — Analytical methods — LCA models

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The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.

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to focus on differences between users, and to avoid bias due to right censoring. Right censoring is a form of missingness that is only taken into account in survival models. When fitting the latent class models, the ten SNPs on CHRNA5/A3/B4 were used to predict differences between classes. Latent class models are fitted with an increasing number of classes. The five phenotypes were analyzed jointly.