abuse or dependence. The mothers’ use of alcohol, drugs, and cigarettes was not available for some participants (alcohol and drug exposure [N=8], cigarette use [N=5]). A total of 75 subjects (HR=36, LR=39) had complete prenatal use data for VBM analysis. Personal use of substances up to the time of the scan was considered by coding each subject for presence or absence of a substance use disorder (SUD).