Chunk #20 — Results — Suppression of AEA/CB1 receptor signaling within the basolateral amygdala complex contributes to stress-induced activation of the HPA axis
that URB597 is optimally effective at a dose of 0.1 μg, presumably due to the fact that greater increases in AEA are believed to lose selectivity for the CB1 receptor and begin to saturate TRPV1 vanilloid receptors (Rubino et al., 2008). Animals that received an infusion of the CB1 receptor antagonist AM251 in conjunction with URB597 exhibited no significant difference in stress-induced corticosterone secretion relative to vehicle infused animals (p > 0.05), supporting the hypothesis that URB597 administration into the BLA, at this dose, reduced HPA axis activation via increased activation of the CB1 receptor by AEA. URB597 infusions into the CeA and MeA were without effect on stress-induced serum corticosterone levels (Table 3).
