Chunk #5 — Background

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Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing.

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Here, we present an Ultra-deep targeted sequencing (UDT-Seq) assay, screening 71.1 kb of sequence encompassing the mutational hotspots of 42 cancer genes. We evaluate its performance and utility by applying it to study the mutational profile of both clinical cancer and mouse xenograft samples.