Laviolette and co-workers also investigated the role of cannabinoid signaling in LTP. LTP was examined using the functional connections between the BA and the prelimbic cortex (Tan et al., 2010). In vivo, tetanic stimulation (HFS, 3 sets of 10 trains,100 Hz) of the ipsilateral BA produced a robust LTP of field potentials within the prelimbic cortex of control rats. This effect was dose-dependently blocked by systemic pretreatment with the CB1 antagonist, AM251, thereby demonstrating that long-term synaptic plasticity along the BA-prelimbic cortex pathway is dependent on CB1 receptor signaling (Tan et al., 2010).
