Neuroimaging studies have consistently cited overall decrements in total cranial, cerebral and cerebellar volumes in FAS subjects140-143. Using segmentation and parcellation techniques, Archibald and colleagues reported volume reductions in parietal, temporal and frontal lobes of the FAS group, with only parietal region showing statistically significant volume reduction after accounting for the overall reduced brain volume. The study had age matched control subjects. No significant volume differences were noted amongst the non-dysmorphic FASD subjects140. A disproportionate cerebral and cerebellar WM volume reduction, pointing towards greater involvement of WM than the gray matter, was noted in FAS subjects. The cerebellar WM volume reduction however did not reach statistical significance140.
