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Chunk #14 — WORKING GROUP CONSIDERATIONS — The Clinical Utility of Incidental Findings

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ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.
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In making these recommendations, the Working Group only addressed the circumstance in which the report of incidental findings would be delivered to the clinician who ordered the clinical sequencing. It was expected that this clinician would contextualize any incidental findings for the patient in light of personal and family history, physical examination, and other relevant findings. This places responsibility for managing incidental findings with the ordering clinician, as we believe that the clinician-patient interaction is the appropriate place for such information to be explained and discussed.21,22