Schendan 2000; Sperling et al 2000). For example, Sperling and colleagues, in a study of 250 alcohol-dependent inpatients, found support for the hypothesis of deviant laterality in the presence of an elevated frequency of developmental risk factors. Type II alcoholic personalities (early drinking onset, antisocial personality characteristics, and refractory to treatment; Cloninger 1987) may be the most vulnerable to thinning of the corpus collosum and perhaps even to emotional processing difficulties (Sperling et al 2000).