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Chunk #21 — 3. Results — 3.2. Changes in gene expression in the Acb-sh and CeA

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Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats.
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In the Acb-sh, there were 154 unique named genes that were differentially altered by adolescent alcohol drinking (Supplemental Table A). Approximately 65% of these genes had a fold-change of 1.15 or higher, and 80 genes (52%) were down-regulated. In the CeA, there were 182 unique named genes that were differentially altered by adolescent alcohol drinking (Supplemental Table B). Approximately 70% of these genes had a fold-change of 1.15 or higher, and 84 genes (46%) were down-regulated. There were 26 genes in common between the 2 regions that were significantly altered by adolescent alcohol drinking (Table 2). All 26 genes had the same directional change in both regions, with nearly identical magnitudes of change.