wider than the unadjusted CIs, and more consistent with those from the replication studies. All the selection adjusted CIs exclude 1, which is consistent with the replication studies. Again, the difference observed between the bias-corrected ORs and the replication study ORs could possibly be explained by the enriched nature of the cases in stage 1. In stage 1, cases were women through clinical genetics centers diagnosed with invasive breast cancer under the age of 60 years who had a family history score of at least 2, where the score was computed as the total number of first-degree relatives plus half the number of second-degree relatives affected with breast cancer [Easton et al., 2007].
