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Chunk #15 — Methods — Ancestry Informative Markers

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Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America.
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differences based on HapMap results in JPT and CHB. TaqMan® SNP genotyping assays were designed for the 184 SNPs and tested using DNA panels. Of these, 128 SNPs passed our quality filters demonstrating reproducible genotyping results in population samples of diverse origin, >90% complete typing results in each population and were in HW equilibrium (p>0.01) in the EURA group. A small number of SNPs were not in HW equilibrium in specific populations (2 SNPs in AFR, 3 SNPs AMI, and 3 SNPs EAS). These SNPs did not overlap between these groups and only 2 SNPs showed HW <0.005). Thus, these SNPs were not excluded, because recent admixture in these self-identified ethnic groups could result in departure from HW. Summary information for the final set of 128 SNPs is provided in Supplementary Table S1.