obtain money than cigarettes, whereas dependent smokers made similar efforts to win money or cigarettes90. A similar group by reward interaction was observed in the right OFC, bilateral DLPFC and left ACC, such that in the occasional smokers these regions showed higher activity to stimuli predicting an increasing monetary reward than to stimuli predicting a cigarette reward, whereas the dependent smokers showed no significant differences in such anticipatory brain activity. These regions also showed higher activation to money in the occasional than in dependent smokers90.