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Chunk #6 — INTRODUCTION

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DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
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(Hook-related protein1) (Simpson et al., 2005), KIAA1212 regulates cytoskeletal dynamics in response to extracellular cues in non-neuronal cells (Enomoto et al., 2006). KIAA1212 is expressed in the developing nervous system and its expression is retained in dentate granule cells of the adult hippocampus (Thompson et al., 2008). The physiological interaction between KIAA1212 and DISC1 has not been characterized and the function of KIAA1212 in neuronal development is unknown.