secondary associations a P-value cut-off of 1 × 10−4 was used as the modelling selection threshold within the GCTA analysis. Results were then extracted for the nine previously reported regions, within which potential secondary signals had been validated from the combined meta-analysis. To be consistent with the look-up threshold for selecting SNVs to carry forward from discovery to replication, results were restricted to SNVs with a significance level of P < 1 × 10−5 from both the discovery meta-analysis and the joint association from GCTA.
