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Chunk #6 — Results — xQTL Discovery

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An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome.
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Using a Bonferroni corrected p-value threshold (αFWER = 0.05, two-tailed), we found (1) 3,388 genes associated with eQTL SNPs (p<8x10−10), (2) 56,973 CG dinucleotides linked to mQTL SNPs (p<5x10−9), and 1,681 H3K9Ac peaks influenced by haQTL SNPs (p<4x10−10) (Figure 1B–C, Table 1). Among the eQTL genes, 133 of them correspond to lincRNAs out of a total of 391 lincRNAs tested. The complete lists of eQTLs, mQTLs, and haQTLs are provided through the xQTL Serve webpage: http://mostafavilab.stat.ubc.ca/xQTLServe.