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Chunk #49 — Discussion — An Enrichment of Associations Implies Shared Genetic Etiology

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Alcohol-related genes show an enrichment of associations with a persistent externalizing factor.
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& Schiöth, 2015), as is MARCH1 (Lee et al., 2016). Lastly, there is preliminary evidence of association between variants in GABRR2 and general cognitive ability (Ma et al., 2016) in a moderately sized (N = 987) Han Chinese sample. The associations with other, non-externalizing forms of psychopathology and with cognitive ability serve as reminder that genetic influences may operate even more broadly, through a general vulnerability to psychopathology, sometimes referred to as the p-factor (Caspi et al., 2014; Pettersson, Larsson, & Lichtenstein, 2016).