Chunk #24 — Polygenic Risk Scores: A Bridge Between Population Variation and Individual Differences — PRS Practicalities — Technical Considerations. — Sample size:

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Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

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performance among healthy individuals; Figure 2, Tables 1–6). As such with optimistic estimates, target data sample sizes of at least 300 are needed to detect 3% of variation with 80% power. Samples of 800, 8,000, and 80,000 would be needed to account for 1%, 0.1%, and 0.01% of variance with 80% power, respectively (computed using GPower; (Faul et al., 2007).