The analyses presented here utilize the candidate gene panel presented in Saccone et al (Saccone et al. 2007), in addition to a number of “fine mapping” SNPs from follow-up genotyping of the nicotinic acetylcholinergic receptor (CHRN) gene family. The initial candidate gene panel consisted of SNPs from genes selected based on known neurobiological and metabolic pathways, previous reports on the genetics of nicotine dependence, and previous reports on the genetics of other psychiatric disorders (see Saccone et al. 2007) for more details on gene and SNP selection). An additional 107 SNPs from 16 CHRN genes were genotyped in a separate experiment to follow-up and fine-map initial discoveries in this gene family (Bierut et al. 2007; Saccone et al. 2007; Saccone et al. 2009).
