other variants according to our integrated non-coding variant functional prediction tool, namely regBase (34) (Supplementary Figure S9D). Third, rs17293632 was found to overlap with most epigenomics signals such as open chromatin, histone modification, and transcription factor binding (Supplementary Figure S9E), particularly in CAD-related tissues/cell types such as the endothelium and blood tissue. Finally, we found that rs17293632 was top-ranked in RegulomeDB and identified as the top causal variant in other complex traits/diseases, such as asthma and inflammatory bowel disease; this further supported its causal and potentially pleiotropic effects. Besides, two recent studies reported that this variant disrupts the binding of the AP-1 transcription factor (51,52).
