All authors contributed to this work. JMV, AFAS, and KJHV initiated and designed the study. RMA and JAP wrote the major parts of the manuscript under the close supervision of AFAS and JMV. RMA organized and cleaned the 25Up data; JAP organized, cleaned, and analyzed the other cohorts (S4S, NTR, and UKB). EMD guided and advised during parts of the data analyses. Furthermore, SDG, IH, NST, BPZ, MDvdZ, BLM, NGM, BF, EJCdG, DIB, DMD, and NAG contributed to the data collection of individual samples, data sharing, and conceptual shaping of the research and manuscript. All authors were involved in reading and reviewing the final manuscript and approved the final submitted documents.
