The strong negative correlation between changes in the RAI and changes in urges to smoke and the association of RAI reductions with failed suppression of DMN activity during a WM task suggest that concurrent alteration of SN-DMN and SNECN couplings may be integral in processing divided attentional resources, cognitive functions, and, in this instance, a clinically relevant symptom of nicotine withdrawal. Further, although many studies43,44 have reported lateralized prefrontal functions, the data-driven GICA not only identified lateralized coherence patterns for the ECN, but the lateralized RAI indicated that each predicted independent but related functions. The RAI for the left hemisphere predicted changes in WM BOLD imaging; for the right hemisphere, changes in craving.
