There are several key differences between LDSC-SEG, which relies on gene expression data without genotypes or eQTLs, and approaches that require eQTL data3,13 (Online Methods, Figure S11, Supplementary Note). Our polygenic approach also differs from other gene expression-based approaches such as SNPsea14,15 and DEPICT17, which restrict their analyses to subsets of SNPs that pass a significance threshold (Supplementary Note, Figures S12-S16, Tables S11-S15).
