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Chunk #37 — RESULTS — Neural Extension II: Duke Neurogenetics Study: fMRI

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Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
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Carriers of the minor (G) allele of rs61826952 had lower left, but not right, reward-related (positive feedback – negative feedback) VS activity when compared to non-carrier individuals in the combined and AA and EA samples (Left: trans-ancestral meta-analysis: beta=−0.041, p=0.008; AA: beta=−0.124, p=0.018; EA: beta=−0.033, p=0.041; Right: trans-ancestral meta-analysis: beta=−0.01, p=0.570). Reward-related VS activity was not significantly associated with rs2418646 genotype (Left: trans-ancestral meta-analysis: beta=−0.007, p=0.560; Right: trans-ancestral meta-analysis: beta=0.0003, p=0.97).