All experiments were carried out with a UK Home Office project licence under the authority of the UK Animals (Scientific Procedures) Act 1986 and in accordance with local guidelines. Experiments were performed at the University of Sussex, which is a designated facility according to the Act. Following the experiments, except where stated otherwise, mice were killed by CO2 inhalation which is an appropriate method under Schedule 1 of the UK Animals (Scientific Procedures) Act 1986.
