Because proteins that interact together are likely to share similar functions, we investigated whether there were shared pathways and biological processes associated with the core composed of our candidate genes and mendelian genes (input list for enrichment in eTable 7 in Supplement 8). These results suggest that there is an enrichment of proteins involved in or regulating the ERBB receptor tyrosine protein kinase signaling pathways (Figure 2C; eTable 8 in Supplement 9).
