In stage 1 (Table 2, Supplementary Table 4 and Supplementary Figs. 3 and 4), 136 associations reached genome-wide significance (P < 5 × 10−8)7. The majority of these associations (N = 129) mapped to 5.5 Mb in the extended major histocompatibility complex (MHC, 6p21.32-p22.1), a region of high linkage disequilibrium (LD) previously implicated in schizophrenia in a subset of the samples used here4,8,9. The other stage 1 regions included new regions (10q24.33 and 8q21.3) and previously reported regions (18q21.2 at TCF4 (encoding transcription factor 4) and 11q24.2 (ref. 8)). The signal at 11q24.2 is ~0.85 Mb from NRGN (encoding neurogranin) and is uncorrelated with the previously associated variant near this gene8.
