statistics for 310 and 71 genes fell below this FDR threshold for caudate and nucleus accumbens, respectively. Of these, 263 and 64 were congruent in the direction of their log fold change across studies (Fig. S5). Using the set of 263 genes from the caudate (i.e., those that were FDR ≤ 0.20 and congruent), we then compared enrichment in this gene set to enrichment found in the 13,348 protein-coding genes we analyzed for DEG that were not found in Lisboa’s DEG set. This analysis yielded 144 enriched gene sets (FDR < 0.05, Table S10), of which 115 were gene ontology or GO terms. We next analyzed these GO terms and their q-values for enrichment using REVIGO to produce a semantic interpretation of these results. Complementing our enrichment analysis of global DEG, the GO enrichment analysis of concordant genes across studies prominently highlights synaptic function (Fig. S6).
