This study, initiated in 1989, recruited high-risk families through adult probands in treatment for alcohol dependence, including probands, their relatives, and community-ascertained comparison families (n=16,848). A prospective study of a subset of adolescents and young adults (aged 12–22) from COGA families was initiated in 2004, with subjects reassessed every two years. Currently, 89% of participants have 2+ interviews completed. All participants and their families provided informed consent/assent, and the study was approved by the corresponding university Institutional Review Board. Full details on data collection have been previously published (34). The current study includes n=1,955 EUR participants from the prospective sample.
