Chunk #65 — Methods — Differential gene and cellular state expression analysis in humans

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Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder.

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We calculated the differential expression in OUD vs. unaffected comparison individuals for two sets of hypotheses:What is the differential expression in each cell type averaged across brain regions and sex?What is the differential expression within the subset of female or male individuals?What is the differential expression interaction between sex and OUD?