which supports the importance of human neuronal models in understanding the synaptic role of alcohol. Finally, the mechanisms of how GABAergic release and GABAA receptor function are impacted by alcohol application in human neurons carrying functionally important and commonly found SNPs that have been linked to alcohol abuse are critical for understanding the initiation and progression of AUDs. This includes OPRM1 A118G, which has been linked to AUDs through GWAS (Hoehe et al., 2000; Berrettini, 2013).
