risk tolerance, automobile speeding propensity, number of sexual partners (45), sensation seeking and drug experimentation (46), cannabis initiation (47), and obesity and body mass index (48–50). CADM2 has also been associated with cognitive phenotypes, including educational attainment (51, 52). We therefore hypothesize that genetic variation at CADM2 may underlie a latent personality trait or risk factor that predisposes individuals to engage in risky actions (i.e. drinking behaviors).
