Evidence from studies of adolescents supports differing etiologies for males and females, suggesting that adolescent girls who are more involved in AOD use than their peers have characteristics reminiscent of the internalizing subtype. Likewise, adolescent boys who use AOD’s have profiles similar to the externalizing subtype (Del Boca et al. 1995). Thus, young people’s responses to their environment, which appear to be connected to their gender, may predict their development of alcohol problems.