Our findings align with an expected relationship between structural and functional abnormalities. For example, significantly explained shared variances showed positive associations of left parsorbitalis, right medial orbitofrontal, right caudal middle frontal cortical volumes, left HV, FA in anteriorly situated frontal WM, superior longitudinal fasciculus, anterior corona radiata, and posteriorly situated left splenium of corpus callosum in the left hemisphere regions with performance on visuospatial memory span and working memory, and their (volumetric and FA measures) negative associations with lower problem-solving ability (Tables 4 and 5), suggesting the role of prefrontal focused circuitry in these cognitive functions. Conversely, FA in left thalamus had a negative association with visuospatial memory performance and a positive association with lower problem-solving ability (Table 5), suggesting that an increase in left thalamic FA may lead to cognitive impairments. Some of these results confirm previously reported volumetric and DTI measures with functional association findings (Colrain et al., 2011, Pfefferbaum et al., 2000, Pitel et al., 2012a). Additionally, combined structural results and relative contributions of different GM and WM regions in explaining shared variance with performance on neuropsychological
