in other settings103. Although genetic correlation analyses restricted to associated variants have also produced important findings97, the power of methods that leverage polygenic signals in genome-wide data is underscored by the discovery of significant genetic correlations involving traits with zero or few genome-wide significant loci, including a significant negative genetic correlation between smoking behavior and educational attainment102. Notably, recent work shows that association statistics for unmeasured traits can be computed using summary statistics from genetically correlated traits104,105.
