Across the age span of 7 to 85 years, resting state functional connectivity (rsFC) increased with age in boys but decreased with age in girls in the dorsolateral prefrontal cortex (DLPFC) (Figure 2C) (Zuo et al. 2010). However, in the amygdala, an opposite pattern was observed with an age-related decrease of rsFC in boys and an age-related increase of rsFC in girls (Zuo et al. 2010). These findings demonstrate gender differences in the developmental trajectory of functional homotopy (i.e. the high degree of synchrony in spontaneous activity between geometrically corresponding interhemispheric regions) in the amygdala and within the DLPFC (Zuo et al. 2010).
