D7S509 (15)), and chromosome 12 (#221 D12S1090 (8)). Evidence on chromosome 7 has been widely replicated in multiple studies [1-4]. However, the location of the red bars representing the most significant markers was not consistent across methods. It should be noted that with 1,000 permutations performed, the lowest empirical p-value that can be attained is p < 0.001, representing the situation in which none of replicate LOD scores was more extreme than the observed LOD score.
