Our examination of whether variants in addition to rs13273442 may contribute to the association between the CHRNB3-CHRNA6 region and nicotine dependence focused on the nearby variant rs4952. The T allele of rs4952 is uncommon in both European Americans (3.0%) and African Americans (0.8%). The variant rs4952 is in linkage disequilibrium with rs13273442, but only modestly correlated to it (r2=0.103, D’=1.0 in European Americans, r2=0.005, D’=1.0 in African Americans).
