We used FUMA to identify SNPs with previously reported (P < 5×10−5) phenotypic associations in published GWAS listed in the NHGRI-EBI catalog28 which overlapped with the genomic risk loci identified in the meta-analysis. As an additional relevant phenotype of interest, we examined whether the genes associated with intelligence in this study (by FUMA mapping or GWGAS) were overrepresented in a set of 1,518 genes linked to intellectual disability and/or developmental delay, as compiled by RegionAnnotater (see URLs). Many of these have been identified by non-GWAS sources and are not represented in the NHGRI catalog. We tested for enrichment using a hypergeometric test with a background set of 19,283 genomic protein-coding genes, as in FUMA. Manual lookups were also performed to identify overlapping loci/genes with known previous GWAS of intelligence.
