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Chunk #9 — Review of Experimental Genetic Approaches — Association Studies and Candidate Genes

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Genetic strategies to detect genes involved in alcoholism and alcohol-related traits.
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methods to make it feasible for genetic laboratories to determine a person’s DNA sequences (i.e., genotypes) for the large number of markers that will be required in genomewide association studies. Finally, new approaches to the statistical analysis of the vast amount of data resulting from such analyses are being developed, as studying such a large number of markers will create problems with multiple testing and increased potential for false positive results—problems that must be resolved before these strategies are feasible.