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Chunk #35 — DISCUSSION

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Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.
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delivered mouse GPCs enhanced neither LTP nor either auditory fear conditioning or Barnes maze performance, strongly suggesting that the potentiation of synaptic plasticity and learning afforded by glial progenitor cell chimerization was specific to human glia, and not a product of cell engraftment per se (Figs. 4B, 6A).